Last updated: November 2026
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Quick verdict: CoQ10 is one of the most popular supplements among adults over 40. For most people, Qunol Ultra CoQ10 100 mg is a simple, affordable choice taken once a day. If you prefer a premium brand with third-party certification, Thorne CoQ10 costs more. Talk to your doctor first if you take a blood thinner.
What is CoQ10?
Coenzyme Q10 (CoQ10) is a substance your body makes on its own. It helps cells produce energy, and it is found in high amounts in the heart. Body levels tend to be lower in older adults and in people taking statin medicines for cholesterol, which is why many people over 40 consider a supplement.
What the research says
The results are mixed. The Mayo Clinic notes that CoQ10 might help with symptoms of congestive heart failure and with preventing migraines. For muscle aches caused by statins, studies point in different directions: some pooled analyses found no benefit, while others found some improvement. Most healthcare professionals consider CoQ10 safe, with few side effects.
Our top pick: Qunol Ultra CoQ10 100 mg
- CoQ10: 100 mg per softgel, in a water- and fat-soluble form
- How to take: 1 softgel a day with food
- Also contains: vitamin E; contains soy
- Typical price: about $21–$30, depending on bottle size
- Why we chose it: the best-selling CoQ10 on Amazon, with a once-a-day dose
Premium alternative: Thorne CoQ10 100 mg
Thorne is known for third-party testing and certification. Its CoQ10 100 mg softgels cost about $53 for 60, so it is a choice for people who value brand quality over price.
Who should talk to a doctor first
- People taking warfarin or other blood thinners — CoQ10 may make warfarin work less well.
- People taking blood pressure medicine — CoQ10 might add to its effect.
- People with heart failure or other heart conditions should only use it with their doctor’s guidance.
- Pregnant or breastfeeding women.
How we wrote this guide: we compared the product labels, prices and the published research on the main ingredients. We did not run our own lab tests. Labels and prices change, so always check the current label before you buy.
These statements have not been evaluated by the Food and Drug Administration. The products mentioned are not intended to diagnose, treat, cure, or prevent any disease. Always talk to your doctor before starting a supplement, especially if you take medication, are pregnant or nursing, or have a health condition.